Old+Test+Questions

Here are some of my old questions for Med. Chem., but they are __not__ related to Chapters 27 and 28, Foye's.

Q1. The following statements are true EXCEPT a. __Acetylation of hydroxyl groups increases the antileukemic activity of vincristine.__ b. Vincristine differs from vinblastine in their toxicities. c. Removal of the acetyl group at C4 of vinblastine destroys its antileukemic activity. d. Vincristine differs from vinblastine only in having an aldehyde moiety.

Q2. Which of the following agents is not an alkylating agent? a. Dacarbazine b. Carboplatin c. Mitomycin __ d. Procarbazine __ e. All of the above are alkylating drugs

Q3. All of the following drugs are natural products EXCEPT a. Mitomycin b. Camptothecin __c. Carboplatin__ d. Paclitaxel

Q4. The following statements are true EXCEPT __ a. Mitotane is a hydrazine derivative __ b. The camptothecins target the nuclear enzyme topoisomerase I. c. (S)-isomer at C20 for camptothecin is at least 10 times more active than (R)-isomer.  Q5. The following statements are true EXCEPT a. __Acetylation of hydroxyl groups increases the antileukemic activity of vincristine.__ b. Vincristine differs from vinblastine in their toxicities. c. Removal of the acetyl group at C4 of vinblastine destroys its antileukemic activity. d. Vincristine differs from vinblastine only in having an aldehyde moiety.

Q6. A 36 yrs old patient has been diagnosed with breast cancer for 12 months. She has received chemotherapeutic treatment twice previously with severe vomiting response. Her physician is now planning to give her a new chemotherapeutic agent which has much less emetic side effect. However, when the patient hears that she is going to receive chemotherapy again, she is immediately feeling nausea and vomiting for 10 min because of her bad memories on previous chemotherapeutic drugs. At this moment, it is better to give her which of the following drugs a. Serotonin agonist b. Serotonin antagonist c. Dopamine agonist d. Dopamine antagonist e. __B__ __enzodiazepine__

Q7. Dr. Richard Kimble (You may have watched Harrison Ford’s “The Fugitive”) is conducting a drug study at a county hospital. He is evaluating the toxicity of a group of chemical agents, as listed below, using rats as model animals. He examined the liver tissue samples of the rats treated with these drugs respectively using H-E staining and microscopy techniques to determine the hepatic toxicity of these drugs in rats. He found that, if significantly overdosed, the hepatic toxicity, indicated by hepatic cell necrosis, of one of these reagents is significantly higher than the rest of them. Which of the following agents is more likely the one that he found? a. __6-thioguanine__ b. 6-mercaptopurine c. Guanine d. Hypoxanthine e. Xanthine